| Angelico Gap Homeowners Association Inc. | — | 0901300 | 2007-03-01 | Active | Murphy |
| Angels Among Us, Inc. | — | 0867378 | 2006-09-19 | Active | Murphy |
| Anne C. Rose Insurance Agency, Inc. | — | 0907814 | 2007-04-11 | Active | Murphy |
| Antica Roma Caffe, LLC | — | 1125650 | 2009-11-30 | Dissolved | Murphy |
| Antler Hunter, Inc. | — | 0768199 | 2005-02-21 | | Murphy |
| Antonietta's Pizzeria, Inc. | — | 0597083 | 2001-07-10 | | Murphy |
| Any Day Photography by Katina, LLC | — | 2517598 | 2022-11-03 | Dissolved | Murphy |
| Apaco Enterprises, Inc. | — | 0883555 | 1981-03-16 | | Murphy, |
| Apalachia Lake Tours, LLC | — | 1456085 | 2015-07-06 | Dissolved | Murphy |
| Apalachia Natural Falls, LLC | — | 0911037 | 2007-05-02 | Dissolved | Murphy |
| Apex Welding & Dock Repair LLC | — | 2606809 | 2023-03-31 | Dissolved | Murphy |
| Appalachia Cove Homeowners Association, Inc. | — | 1212388 | 2011-07-13 | Active | Murphy |
| Appalachia Craftsman, LLC | — | 2132606 | 2021-02-15 | Dissolved | Murphy |
| Appalachia Distilling Company, LLC | — | 2583526 | 2023-02-27 | Dissolved | Murphy |
| Appalachia Hills Developers, Inc. | — | 0743015 | 2004-09-10 | Dissolved | Murphy |
| Appalachia Village Home Owners Association | — | 0168429 | 1985-06-06 | Merged | Murphy |
| Appalachian Access | — | 1497747 | 2016-02-12 | Active | Murphy |
| Appalachian Angels of the 30th Judicial District, Inc. | — | 0476365 | 1998-11-18 | Active | Murphy |
| Appalachian Art & Framing, Inc. | — | 1073686 | 2008-12-01 | | Murphy |
| Appalachian Attitude Softball | — | 3209338 | 2026-02-09 | Active | Murphy |
| Appalachian Auto Rentals, Inc | — | 1529849 | 2016-07-11 | | Murphy |
| Appalachian Autoworks, LLC | — | 3159918 | 2025-10-31 | Active | Murphy |
| Appalachian Bonding Company, Inc. | — | 0721290 | 2004-04-16 | | Murphy |
| Appalachian Built Co. | — | 3367734 | 2026-08-26 | Active | Murphy |
| Appalachian Children and Family Services Inc. | — | 0890057 | 2006-12-22 | Active | Murphy |
| Appalachian Community Services, Inc. | — | 0873742 | 2006-10-24 | | Murphy |
| Appalachian Derm Center, Inc. | — | 2266942 | 2021-09-10 | Active | Murphy |
| Appalachian Energy Services LLC | — | 0821255 | 2006-01-06 | Dissolved | Murphy |
| Appalachian Fire Safety Inc. | — | 0285722 | 1991-04-09 | | Murphy |
| Appalachian Frame and Body, Inc. | — | 0019313 | 1984-07-03 | Dissolved | Murphy |
| Appalachian Gold LLC | — | 3027264 | 2025-04-16 | Active | Murphy |
| Appalachian Heating & Air, Inc. | — | 1688652 | 2018-04-09 | Active | Murphy |
| Appalachian Highland Games, Inc. | — | 0713860 | 2004-03-01 | Dissolved | Murphy |
| Appalachian Lady Homesteaders, Inc. | — | 2888200 | 2024-08-21 | Active | Murphy |
| Appalachian Land Development, LLP | — | 3159949 | 2025-11-04 | Active | Murphy |
| Appalachian Motor Company | — | 0251921 | 1989-07-11 | | Murphy |
| Appalachian Mountain Manor, LLC | — | 0741827 | 2004-09-02 | Dissolved | Murphy |
| Appalachian Mountain Myofunctional Therapy, LLC | — | 2848082 | 2024-05-21 | Dissolved | Murphy |
| Appalachian Mountain Wholesale LLC | — | 2924057 | 2024-10-01 | Dissolved | Murphy |
| Appalachian Mountain and Lake Properties LLC | — | 1272857 | 2012-08-09 | Active | Murphy |
| Appalachian Natural Health Center, Inc. | — | 0801224 | 2005-09-06 | Active | Murphy |
| Appalachian Networks LLC | — | 1145038 | 2010-04-21 | Dissolved | Murphy |
| Appalachian Outfitters of Murphy, Inc. | — | 0846488 | 2006-05-17 | | Murphy |
| Appalachian Paint & Body, LLC | — | 2019914 | 2020-07-31 | Dissolved | Murphy |
| Appalachian Properties, Inc. | — | 0000212 | 1972-07-31 | Active | Murphy |
| Appalachian RV Service, Inc. | — | 0583110 | 2001-03-05 | Dissolved | Murphy |
| Appalachian Repair and Restoration, LLC | — | 3177157 | 2026-01-01 | Active | Murphy |
| Appalachian Rolled Ice Cream LLC | — | 2618573 | 2023-04-21 | Dissolved | Murphy |
| Appalachian Screen & Porch, LLC | — | 1069517 | 2008-10-28 | Dissolved | Murphy |
| Appalachian Tattoo Center LLC | — | 3016886 | 2025-04-02 | Active | Murphy |